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小分子再生医学药物的发现到多肽,业余高尔夫

时间:2019-08-26 10:29来源:科学研究
1.Oral insulin composite microcapsules and manufacturing method thereof(by machine translation). CN104739806, 2018. 001 Tales from the war on error: the art and science of curating QSARdata. IF=3.199 应自己校生命科学大学邓成教师

1.Oral insulin composite microcapsules and manufacturing method thereof (by machine translation). CN104739806, 2018.

001 Tales from the war on error: the art and science of curating QSAR data. IF=3.199

应自己校生命科学大学邓成教师和西藏省生化与分子生物学学会青少年委员会的约请,U.S.A.Scripps切磋所和弗吉尼亚州生物医药切磋所斟酌员杨鹏宇博士定于二〇一四年1月5日上午11点做学术报告。

 

2.A oral insulin nano-composite and its preparation method (by machine translation). CN108236720, 2018.

Waldman M, Fraczkiewicz R, and Clark RD. (2015) J Comput Aided Mol Des. 29(9), 897-910.

讲座人:杨鹏宇学士

  三月17日新加坡新闻:二零一二年房山长阳炎黄业余高尔夫球季军赛第一群较量在京城加州水郡高尔夫俱乐部甘休,曹一交72杆得到男人超越。王梓漪交出71杆与菲律宾球员维多Cordova共同当先女孩子。前日将扩充第2轮争夺,第一组球员在早晨8时起程。王梓漪将与冈村优、马家嵋一组将于9:30在10号洞出发。以下是参加比赛球员第2轮分组:

3.Traditional Chinese medicine formula for improving insulin resistance. CN107812134, 2018.

002 Discovery of new acetylcholinesterase inhibitors with small core structures through shape-based virtual screening   IF=2.486

U.S.Scripps切磋所和西弗吉尼亚州生物医药商量所研商员(Institute Fellow)

Round 2 (October 15, 2011)                         DRAW —— Tee 1

4.A oral insulin nano particle and its preparation method (by machine translation). CN108371708, 2018.

Chen Y, Liu Z, Fu T, Li W, Xu X, Sun H. Bioorg. & Med. Chem. Lett., 2015, 25, 3442-3446.

告诉标题:小分子再生经济学药物的发现到多肽/矿物质药物的研究开发

FLIGHT

5.A oral insulin [...] grain and its preparation method (by machine translation). CN108478785, 2018.

003 Assessment of in silico models for acute aquatic toxicity towards fish under REACH regulation. IF=1.596

时间:2016年7月5日中午11点

 TIME

6.AboulFotouh, K.; Allam, A. A.; El-Badry, M.; El-Sayed, A. M., Role of self-emulsifying drug delivery systems in optimizing the oral delivery of hydrophilic macromolecules and reducing interindividual variability. Colloids and Surfaces B: Biointerfaces 2018, 167, 82 - 92.

Cappelli CI, Cassano A, Golbamaki A, Lombardo A,Colafranceschi M, Benfenati E. SAR and QSAR in Environmental Research, online Nov. 2015.

地点:生科院三楼圆形会场

 PLAYER

7.Achenbach, Asymptomatic early stage type?1 diabetes: Oral insulin as a?preventive treatment. Diabetologe 2018, 14 , 234 - 239.

004 Benzazaborinines as novel bioisosteric replacements of naphthalene: propranolol as an example.  IF=5.589

杨博士于二零一三年获新加坡共和国国立高校军事学大学生学位,时期根本钻探方向为依靠活性的维生素组剖析本领在规定活性小分子、天然产物的海洋生物靶点中的开辟及运用。结业后投入U.S.Scripps探讨所和亚利桑那州生物医药研讨所彼得G. Schultz院士的调查研商共青团和少先队,从事生物活性小分子,多肽/纤维素,抗体药物的研商和支付,在慢性高血糖、肥胖、癌症的靶向免疫医治领域有深厚的钻探。开采并判断了抑制 Hippo 通路的斩新小分子化合物,能够用来临床退行性病痛,体内协会和器官原来的地方修复及再生。创设了一种新的“装订”技巧平台,并使用于以内源性多肽荷尔蒙的无尽长效多肽药物的临床化合物的斟酌开辟。已在PNAS,Chemistry & Biology,JACS,ANGEW等国际权威性杂志上发表了30 多篇科学杂文,引用次数超越1200次,申请了4项国际发明专利,相关工作被P陆风X8Newswire, GlobeNewswire, Bionity,Faculty of 一千等评价。是“Chemistry & Biology”,“ACS Chemical Biology”,“Organic & Biomolecular Chemistry”,“Medicinal Research Review”,“安德拉SC Advances”,“European Journal of Medicinal Chemistry”等20多个期刊的特约审阅稿件人。在二零零六年取得中国政坛公布的天涯留学生奖-国家非凡自费留学生奖学金。

GENDER

8.Alfatama, M.; Lim, L. Y.; Wong, T. W., Alginate-C18 Conjugate Nanoparticles Loaded in Tripolyphosphate-Cross-Linked Chitosan-Oleic Acid Conjugate-Coated Calcium Alginate Beads as Oral Insulin Carrier. Molecular Pharmaceutics 2018, 15 , 3369 - 3382.

Rombouts FJR, Tovar F, Austin N, Tresadern G, Trabanco AA. J. Med. Chem., Just Accepted Manuscript, Nov. 13, 2015.

杨大学生告诉中,将探求小分子再生艺术学药物的发掘与多肽/抗体药物的付出平台。在告诉的前半局地首要钻探基于Hippo时域信号通路,筛选转录效应因子YAP的小分子激动剂,在成员、细胞及格局动物体内皮肤再生进程的求证。在告诉的后半片段,将商量一种新的“装订”本事平台在内源性多肽荷尔蒙的每家每户长效多肽药物开采中的应用。

新豪天地登录网址,FROM

9.Anirudhan, T. S.; Parvathy, J., Novel Thiolated Chitosan-Polyethyleneglycol blend/Montmorillonite composite formulations for the oral delivery of insulin. Bioactive Carbohydrates and Dietary Fibre 2018, 16, 22 - 29.

005 Pharmacologic Activities of 3'-Hydroxypterostilbene: Cytotoxic, Anti-Oxidant, Anti-Adipogenic, Anti-Inflammatory, Histone Deacetylase and Sirtuin 1 Inhibitory Activity.  IF=2.59

应接感兴趣的教授同学前来沟通。

TO PAR

10.Babbar, R.; Heni, M.; Peter, A.; de Angelis, M. H.; H?ring, H.-U.; Fritsche, A.; Preissl, H.; Sch?lkopf, B.; Wagner, R. b., Prediction of glucose tolerance without an oral glucose tolerance test. Frontiers in Endocrinology 2018, 9 .

Takemoto JK, Remsberg CM, Davies NM. J. Pharm. Pharm. Sci 18(4) 713-727, 2015

1P.-Y. Yang, H. Zou, E. Chao, L. Sherwood, V. Nunez, M. Keeney, E. Ghartey-Tagoe, Z. Ding, H. Quirino, X. Luo, G. Welzel, G. Chen, P. Singh, A.K. Woods*, P.G. Schultz*, W. Shen* “Engineering a Long-Acting, Potent GLP-1 Analogue for Microstructure-Based Transdermal Delivery” Proc. Natl. Acad. Sci. USA 2016,113, 4140-4145. (In the News: PR Newswire, GlobeNewswire, Bionity)

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11.Banerjee, A.; Ibsen, K.; Brown, T.; Chen, R.; Agatemor, C.; Mitragotri, S., Ionic liquids for oral insulin delivery. Proceedings of the National Academy of Sciences of the United States of America 2018, 115 , 7296 - 7301.

006 Analysis of Intra- and Intersubject Variability in Oral Drug Absorption in Human Bioequivalence Studies of 113 Generic Products.   

2X. Luo, C. Zambaldo, T. Liu, Y. Zhang, W. Xuan, C.Wang, S.A. Reed, P.-Y. Yang, R.E. Wang, T. Javahishvilli, P.G. Schultz*, T.S. Young* “Recombinant Thiopeptides with Noncanonical Amino Acids” Proc. Natl. Acad. Sci. USA 2016, 113, 3615-3620.

8:00

12.Barbari, G. R.; Dorkoosh, F.; Amini, M.; Javan, N. B.; Sharifzadeh, M.; Atyabi, F.; Balalaie, S.; Tehrani, N. R.; Tehrani, M. R., Synthesis and characterization of a novel peptide-grafted cs and evaluation of its nanoparticles for the oral delivery of insulin, in vitro, and in vivo study. International Journal of Nanomedicine 2018, 13, 5127 - 5138.

Sugihara M, Takeuchi S, Sugita M, Higaki K, Kataoka M,Yamashita S. Mol. Pharmaceutics, Article ASAP Nov. 15, 2015.

3Y. Cao, D.T. Rodgers, J. Du, I. Ahmad, E. N. Hampton, J. Ma, M.Mazagova, S. Choi, H. Yun, H. Xiao, P.-Y. Yang, X. Luo, R. Lim, H. Pugh, F. Wang, S.A. Pinkerton, T.M. Wright, C.H. Kim*, P.G. Schultz*, T.S. Young* “Design of Switchable Chimeric Antigen Receptor T Cells Targeting Breast Cancer” Angew. Chem. Int. Ed.2016, in press.

杨伊农

13.Bhattacharyya, A.; Nasim, F.; Mishra, R.; Bharti, R. P.; Kundu, Polyurethane-incorporated chitosan/alginate core?shell nano-particles for controlled oral insulin delivery. Journal of Applied Polymer Science 2018, 135 .

007 Tools for early prediction of drug loading in lipid-based formulations.  IF=4.384

4A. Muppidi, H. Zou, P.-Y. Yang, E. Chao, L. Sherwood, V. Nunez, A.K. Woods, P.G. Schultz*, Q. Lin*, W. Shen* “Design of Potent and Proteolytically Stable Oxyntomodulin Analogs”, ACS Chem. Biol.2016,11, 324-328.

Y N Yang

14.Chen, C. C.; Baikoghli, M. A.; Cheng, R. H., Tissue targeted nanocapsids for oral insulin delivery via drink. Pharmaceutical Patent Analyst 2018, 7 , 121 - 127.

Alskar LC, Porter CJH, Bergstrom CAS. Mol. Pharmaceuticals, web., Nov. 15, 2015.

5P.-Y. Yang, K. Liu* “Activity-Based Protein Profiling: Recent Advances in Probe Development and Applications”, ChemBioChem. 2015, 16, 712-724.

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15.Chen, J.; Liu, R.; Liu, C.; Jin, X.; Zhang, Q.; Wang, J.; Zhao, F.; Wang, Z.; Qiu, H.; Li, Y.; Yi, X., Progress of oral insulin and related drug delivery systems and their pharmacokinetics. Current Drug Metabolism 2018, 19 , 863 - 870.

008 A review of the current state of the art of physiologically-based tests for measuring human dermal in vitro bioavailability of polycyclic aromatic hydrocarbons (PAH) in soil. IF=4.529

6H. Xiao, F.B. Peters, P.-Y. Yang, S. Reed, J.R. Chittuluru, P.G. Schultz*, “Genetic Incorporation of Histidine Derivatives Using an Engineered Pyrrolysyl-tRNASynthetase”, ACS Chem. Biol.2014, 9, 1092-1096.

CHN

16.Chen, Y.; Li, P.; Modica, J. A.; Drout, R. J.; Farha, O. K., Acid-Resistant Mesoporous Metal-Organic Framework toward Oral Insulin Delivery: Protein Encapsulation, Protection, and Release. Journal of the American Chemical Society 2018, 140 , 5678 - 5681.

Beriro DJ, Cave MR, Wragg J, Thomas R,Wills G, Evansc F. J. Hazardous Materials, Available online 18 November 2015.

7F. Wang, D. Sambandan, J. Wang, R. Halder, S. Batt, B. C. Weinrick, I. Ahmad, P.-Y. Yang, Y. Zhang, J. Kim, M. Hassani, S. Huszar, K. Mikusova, A. Chatterjee, G. Besra, K. Futterer, W. R. Jacobs*, P. G. Schultz*, “Identification of a Small Molecule with Activity against Drug-resistant and Persistent Tuberculosis”, Proc. Natl. Acad. Sci. USA 2013, 110, E2510-E2517.

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17.Chen, Y.-S.; Zaro, J. L.; Zhang, D.; Huang, N.; Simon, A.; Shen, W.-C., Characterization and oral delivery of proinsulin-transferrin fusion protein expressed using expresstec. International Journal of Molecular Sciences 2018, 19 .

009 Tales from the war on error: the art and science of curating QSAR data.  IF= 3.199

8A. Chatterjee, H. Xiao, P.-Y. Yang, G. Soundararajan, P. G. Schultz*, “A Tryptophanyl-tRNASynthetase/tRNA Pair for Unnatural Amino Acid Mutagenesis in E. coli”, Angew. Chem. Int. Ed.2013, 52, 5106-5109.

范无名

18.Cikrikci, S.; Mert, B.; Oztop, M. H., Development of pH Sensitive Alginate/Gum Tragacanth Based Hydrogels for Oral Insulin Delivery. Journal of Agricultural and Food Chemistry 2018, 66 , 11784 - 11796.

Waldman M, Fraczkiewicz R, and Clark RD. (2015) J Comput Aided Mol Des. 29(9), 897-910.

9N. Nasheri, M. Joyce, Y. Rouleau, P.-Y. Yang, S. Yao, D. L. Tyrrell, J. P. Pezacki*, “Modulation of Fatty Acid Synthase Enzyme Activity and Expression during Hepatitis C Virus Replication”, Chem. Biol.2013, 20, 570-582.

W M Fan 

19.Czuba, E.; Diop, M.; Mura, C.; Schaschkow, A.; Langlois, A.; Bietiger, W.; Neidl, R.; Virciglio, A. l.; Auberval, N.; Julien-David, D.; Maillard, E.; Frere, Y.; Marchioni, E.; Pinget, M.; Sigrist, S. v., Oral insulin delivery, the challenge to increase insulin bioavailability: Influence of surface charge in nanoparticle system. International Journal of Pharmaceutics 2018, 542 , 47 - 55.

010 Assessment of in silico models for acute aquatic toxicity towards fish under REACH regulation. IF= 1.897

10D. Wang, J. Wang, G. M. C. Bonamy, S. Meeusen, R. G. Brusch, C. Turk, P.-Y. Yang, P. G. Schultz*, “A Small Molecule Promotes Mitochondrial Fusion in Mammalian Cells”, Angew. Chem. Int. Ed.2012, 51, 9302-9305.

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20.Danne, T.; Heinemann, L.; Bolinder, J., New Insulins, Biosimilars, and Insulin Therapy. Diabetes Technology and Therapeutics 2018, 20 , S55

Cappelli CI, Cassano A, Golbamaki A, Lombardo A,Colafranceschi M, Benfenati E. SAR and QSAR in Environmental Research, online Nov. 2015.

11P.-Y. Yang, K. Liu, M. N. Ngai, M. J. Lear, M. R. Wenk, S. Q. Yao*, “Activity-Based Proteome Profiling of Potential Cellular Targets of Orlistat  an FDA-Approved Drug with Anti-Tumor Activities”, J. Am. Chem. Soc. 2010, 132, 656-666. (highlighted by Faculty of 1000 Biology)

CHN

  • S70.

011-020

12P.-Y. Yang, M. Wang, K. Liu, M. H. Ngai, O. Sheriff, M. J. Lear, S. K. Sze, C. Y. He, S. Q. Yao*, “Parasite-Based Screening and Proteomic Profiling Reveals Orlistat, an FDA-Approved Drug, as a Potential Anti-Trypanosomabrucei Agent”, Chem. Eur. J. 2012, 18, 8403-8413.

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21.Dellepiane, S.; Ben Nasr, M.; Assi, E.; Usuelli, V.; Letizia, T.; D'Addio, F.; Zuccotti, G. V.; Fiorina, P., Sodium glucose cotransporters inhibitors in type 1 diabetes. Pharmacological Research 2018, 133, 1 - 8.

011 Benzazaborinines as novel bioisosteric replacements of naphthalene: propranolol as an example. IF= 5.589

13P.-Y. Yang, M. Wang, L. Li, H. Wu, C. Y. He, S. Q. Yao*, “Design, Synthesis and Biological Evaluation of Potent Azadipeptide Nitrile Inhibitors and Activity-Based Probes as Promising Anti-Trypanosoma brucei Agents”, Chem. Eur. J. 2012, 18, 6528-6541.

 

22.Dumont, C.; Bourgeois, S.; Fessi, H.; Jannin, V., Lipid-based nanosuspensions for oral delivery of peptides, a critical review. International Journal of Pharmaceutics 2018, 541 , 117 - 135.

Rombouts FJR, Tovar F, Austin N, Tresadern G, Trabanco AA. J. Med. Chem., Just Accepted Manuscript, Nov. 13, 2015.

14P.-Y. Yang, M. Wang, C. Y. He, S. Q. Yao*, “Activity-Based Proteome Profiling of Potential Cellular Targets of K11777 - a Clinical Cysteine Protease Inhibitor”, Chem. Commun.2012, 48, 835-837.

 

23.Easa, N.; Alany, R. G.; Carew, M.; Vangala, A., A review of non-invasive insulin delivery systems for diabetes therapy in clinical trials over the past decade. Drug Discovery Today 2018.

012 Pharmacologic Activities of 3'-Hydroxypterostilbene: Cytotoxic, Anti-Oxidant, Anti-Adipogenic, Anti-Inflammatory, Histone Deacetylase and Sirtuin 1 Inhibitory Activity. IF= 2.59

15P.-Y. Yang, K. Liu, C. Zhong, G.Y.J. Chen, Y. Shen, M. H. Ngai, M. J. Lear, S. Q. Yao*, “Chemical Modification and Organelle-Specific Localization of Orlistat-Like Natural Product-Based Probes”, Chem. Asian. J. 2011, 6, 2762-2775.

 

24.Eilleia, S. Y.; Soliman, M. E.; Mansour, S.; S. Geneidi, A., Novel technique of insulin loading into porous carriers for oral delivery. Asian Journal of Pharmaceutical Sciences 2018, 13 , 297 - 309.

Takemoto JK, Remsberg CM, Davies NM. J. Pharm. Pharm. Sci 18(4) 713-727, 2015  

16P.-Y. Yang, H. Wu, M. Y. Lee, A. Xu, R. Srinivasan, S. Q. Yao*, “Solid-Phase Synthesis of Azidomethylene Inhibitors Targeting Cysteine Proteases”, Org. Lett. 2008,10, 1881-1884.

 

25.Eilleia, S. Y.; Soliman, M. E.; Niedermayer, S.; Schmidt, A.; Mansour, S.; Geneidi, A. S., Examining insulin adsorption onto mesoporous silica microparticles for oral delivery. Current Drug Delivery 2018, 15 , 541 - 553.

013 Analysis of Intra- and Intersubject Variability in Oral Drug Absorption in Human Bioequivalence Studies of 113 Generic Products.  IF=4.342

17P.-Y. Yang, Y.-G. Zhou*, “The Enantioselective Total Synthesis of Alkaloid -Galipeine”, Tetrahedron: Asymmetry2004, 15, 1145-1149.

 

26.Fan, W.; Xia, D.; Zhu, Q.; Li, X.; He, S.; Zhu, C.; Guo, S.; Hovgaard, L.; Yang, M.; Gan, Y., Functional nanoparticles exploit the bile acid pathway to overcome multiple barriers of the intestinal epithelium for oral insulin delivery. Biomaterials 2018, 151, 13 - 23.

Sugihara M, Takeuchi S, Sugita M, Higaki K, Kataoka M,Yamashita S. Mol. Pharmaceutics, Article ASAP Nov. 15, 2015.

18Y.-G. Zhou*, P.-Y. Yang, X.-W. Han, “Synthesis and Highly Enantioselective Hydrogenation of Exocyclic Enamides: -3- Arylidene-4-acetyl-3,4-dihydro-2H-1,4-benzoxazines”, J. Org. Chem. 2005, 70, 1679-1683.

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27.Fuadah, N. R.; Hertadi, R., In Silico Study of Phospholipids as An Oral Insulin Delivery System. Journal of Physics: Conference Series 2018, 1090 .

014 Tools for early prediction of drug loading in lipid-based formulations.     

19J.-C. Shi*, P.-Y. Yang, Q. Tong, L. Jia, “Palladium-Catalyzed Aminations of Aryl Halides with Phosphine-Functionalized Imidazolium Ligands”, Dalton Trans.2008, 938–945.

8:10

28.Fukuoka, Y.; Khafagy, E.-S.; Goto, T.; Kamei, N.; Takayama, K.; Peppas, N. A.; Takeda-Morishita, M., Combination strategy with complexation hydrogels and cell-penetrating peptides for oral delivery of insulin. Biological and Pharmaceutical Bulletin 2018, 41 , 811 - 814.

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20J.-C. Shi*, P.-Y. Yang, Q. Tong, Y. Wu, Y. Peng, “Highly Efficient and Stable Palladium/Imidazolium Salt-Phosphine Catalysts for Suzuki–Miyaura Cross-Coupling of Aryl Bromides”, J. Mol. Catal. A: Chem. 2006, 259, 7-10.

向堉銓

29.Gabbai, F. B., The role of renal response to amino acid infusion and oral protein load in normal kidneys and kidney with acute and chronic disease. Current Opinion in Nephrology and Hypertension 2018, 27 , 23 - 29.

015  A review of the current state of the art of physiologically-based tests for measuring human dermal in vitro bioavailability of polycyclic aromatic hydrocarbons (PAH) in soil.   IF=4.836

21W.B. Wang, S.-M. Lu, P.-Y. Yang, X.-W. Han, Y.-G. Zhou*, “Highly Enantioselective Iridium-Catalyzed Hydrogenation of Heteroaromatic Compounds, Quniolines”, J. Am. Chem. Soc. 2003, 125, 10536-10537.

Y C Hsiang

30.Gedawy, A.; Martinez, J.; Al-Salami, H.; Dass, C. R., Oral insulin delivery: existing barriers and current counter-strategies. Journal of Pharmacy and Pharmacology 2018, 70 , 197 - 213.

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22K. Liu, P.-Y. Yang, Z. Na, S. Q. Yao*, “Dynamic Monitoring of Newly Syntheisized Proteomes: Up-Regulation of Myristoylated Protein Kinase A During Butyric Acid Induced Apoptosis”, Angew. Chem. Int. Ed.2011, 50, 6776-6781.

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31.Harris, K.; Boland, C.; Meade, L.; Battise, D., Adjunctive therapy for glucose control in patients with type 1 diabetes. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2018, 11, 159 - 173.

016 The use of computational chemistry to predict toxicity of antioxidants food additives and its metabolites as a reference for food safety regulation.   IF=6.567

23H. Wu, J. Ge, P.-Y. Yang, J. Wang, M. Uttamchandani, S. Q. Yao*, “A Peptide Aldehyde Microarray for High-Throughput Detection of Cellular Events”, J. Am. Chem. Soc.2011, 133, 1946-1954.

TPE

32.He, H.; Lu, Y.; Qi, J.; Zhao, W.; Dong, X.; Wu, W., Biomimetic thiamine- and niacin-decorated liposomes for enhanced oral delivery of insulin. Acta Pharmaceutica Sinica B 2018, 8 , 97 - 105.

Damayanti S, Permana J, Tjahjono DH. Der Pharma Chemica, 2015, 7(9):174-181.

24M. Hu, L. Li, H. Wu, Y. Su, P.-Y. Yang, M. Uttamchandani, S. Q. Yao*, “Multi-Color, One- and Two-Photon Imaging of Enzymatic Activities in Living Cells with Novel Fluorescently Quenched Activity-Based Probes ”, J. Am. Chem. Soc.2011, 133, 12009-12020.

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33.He, Z.; Liu, Z.; Tian, H.; Hu, Y.; Liu, L.; Leong, K. W.; Mao, H.-Q.; Chen, Y., Scalable production of core-shell nanoparticles by flash nanocomplexation to enhance mucosal transport for oral delivery of insulin. Nanoscale 2018, 10 , 3307 - 3319.

017 Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity.

25M. H. Ngai, P.-Y. Yang, Y. Shen, S. Q. Yao*, M. J. Lear*, “Click-Based Synthesis and Proteomic Profiling of Lipstatin Analogues”, Chem. Commun.2010, 46, 8335-8337. (Cover Feature Article)

石池勋

34.Hu, Q.; Luo, Y., Recent advances of polysaccharide-based nanoparticles for oral insulin delivery. International Journal of Biological Macromolecules 2018, 120, 775 - 782.

Paraskevopoulos G,Krátký M,Mandíková J, Trejtnar F, Stolaríková J, Pávek P,Besra G, Vinšová J. Bioorg. and Med. Chem., Available online 24 October 2015. 

26L. P. Tan, H. Wu, P.-Y. Yang, K. A. Kalesh, X. Zhang, M. Hu, R. Srinivasan, S. Q. Yao*, “High-Throughput Discovery of Mycobacterium Tuberculosis Protein Tyrosine Phosphatase Inhibitors Using Click Chemistry”, Org. Lett.2009,11, 5102-5105.

Seok Ji Hun

35.Ibie; Knott; Thompson, Complexation of novel thiomers and insulin to protect against in vitro enzymatic degradation?towards oral insulin delivery. Drug Development and Industrial Pharmacy 2018.

018 In vitro anticancer properties and biological evaluation of novel natural alkaloid jerantinine B. IF=5.992

27R. Srinivasan,L. P. Tan, H. Wu, P.-Y. Yang, K. A. Kalesh, S. Q. Yao*, “High-Throughput Synthesis of Azide Libraries Suitable for Direct “Click” Chemistry and in situ Screening”, Org. Biol. Chem., 2009, 7, 1821-1828.

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36.Ismail, H. M.; Xu, P.; Libman, I. M.; Becker, D. J.; Marks, J. B.; Skyler, J. S.; Palmer, J. P.; Sosenko, J. M., The shape of the glucose concentration curve during an oral glucose tolerance test predicts risk for type 1 diabetes. Diabetologia 2018, 61 , 84 - 92.

Qazzaz ME, Raja VJ, Lim K, Kam T, Lee JB, Gershkovich P, Bradshaw TD. Cancer Letters, online Oct. 26, 2015.  

28S. L. Ng, P.-Y. Yang, K.Y.-T. Chen, R. Srinivasan, S. Q. Yao*, “Click Synthesis of Small-Molecule Inhibitors Targeting Caspases”,Org. Biomol. Chem., 2008, 6, 844–847.

KOR

37.Jafary Omid, N.; Bahari Javan, N.; Dehpour, A.-R.; Partoazar, A.; Rafiee Tehrani, M.; Dorkoosh, F., In-vitro and in-vivo cytotoxicity and efficacy evaluation of novel glycyl-glycine and alanyl-alanine conjugates of chitosan and trimethyl chitosan nano-particles as carriers for oral insulin delivery. International Journal of Pharmaceutics 2018, 535 , 293 - 307.

019 The evolution and future of environmental partition coefficients.  

29K. A. Kalesh, P.-Y. Yang, R. Srinivasan, S. Q. Yao*, “Click Chemistry as a High-Throughput Amenable Platform in Catalomics”, QSAR Comb. Sci. 2007, 26, 1135–1144.

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38.Jung, S.-H.; Jung, C.-H.; Reaven, G. M.; Kim, S. H., Adapting to insulin resistance in obesity: role of insulin secretion and clearance. Diabetologia 2018, 61 , 681 - 687.

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30H.-W. Yu, J.-C. Shi*, H. Zhang, P.-Y. Yang, X.-P. Wang, Z.-L. Jin, “Unsymmetric-1,3-Disubstituted Imidazolium Salt for Palladium-Catalyzed Suzuki–Miyaura Cross-Coupling Reactions of Aryl Bromides”, J. Mol. Catal. A: Chem. 2006, 250, 15-19.

华成思

39.Kamei, N.; Shigei, C.; Hasegawa, R.; Takeda-Morishita, M., Exploration of the key factors for optimizing the in vivo oral delivery of insulin by using a noncovalent strategy with cell-penetrating peptides. Biological and Pharmaceutical Bulletin 2018, 41 , 239 - 246.

020 Discovery of New Scaffolds from Approved Drugs as Acetylcholinesterase Inhibitors. IF=2.45

31G. Yang, X.-W. Han, W.-P. Zhang, X.-M. Liu, P.-Y. Yang, Y.-G. Zhou, X.-H. Bao*, “Study on Conformation Interconversion of 3-Alkyl-4-acetyl-3,4-dihydro-2H-1,4-benzoxazines from Dynamic NMR Experiments and ab Initio Density Functional Calculations”, J. Phys. Chem. B2005, 109, 18690-18698.

C S Hua

40.Kassem, M.; Ali, A.; El-badrawy, A., Formulation, characterization and in-vivo application of oral insulin nanotechnology using different biodegradable polymers: Advanced drug delivery system. International Journal of Pharmaceutical Sciences and Research 2018, 9 , 3664 - 3677.

Chen, Y, Xu X, Fu T, Li W, Liu Z, Sun H. RSC Adv., 2015,5, 90288-90294.

PATENTS

M

41.Kermanizadeh, A.; Powell, L. G.; Stone, V.; M?ller, P., Nanodelivery systems and stabilized solid-drug nanoparticles for orally administered medicine: Current landscape. International Journal of Nanomedicine 2018, 13, 7575 - 7605.

021-030

1.W. Shen, P. Yang, H. Zhou, P.G. Schultz,“Modified Therapeutic Agents, Stapled Peptide Lipid Conjugates, and Compositions Thereof”, WO2015095406.

CHN

42.Kesharwani, P.; Gorain, B.; Low, S. Y.; Tan, S. A.; Ling, E. C. S.; Lim, Y. K.; Chin, C. M.; Lee, P. Y.; Lee, C. M.; Ooi, C. H.; Choudhury, H.; Pandey, M., Nanotechnology based approaches for anti-diabetic drugs delivery. Diabetes Research and Clinical Practice 2018, 136, 52 - 77.

021 Development of Physiologically Based Pharmacokinetic/Pharmacodynamic Model for Indomethacin Disposition in Pregnancy.  IF=3.057

2.W. Shen, P. Yang, P.G. Schultz, “Modified Therapeutic Agents and Compositions Thereof” US62180856.

8

43.Kihl, P.; Krych, L.; Buschard, K.; Wesley, J. D.; Kot, W.; Hansen, A. K.; Nielsen, D. S.; von Herrath, M. G., Oral insulin does not alter gut microbiota composition of NOD mice. Diabetes/Metabolism Research and Reviews 2018, 34 .

S Alqahtani, A Kaddoumi , PLOS One, October 2015.

3.W. Shen, P.G. Schultz,A.Muppidi,A.Crameri, I. Ahmad, P. Yang,“Modified Therapeutic Agents and Compositions Thereof” WO2015038938.

3

44.Kou, L.; Bhutia, Y. D.; Yao, Q.; He, Z.; Sun, J.; Ganapathy, V., Transporter-guided delivery of nanoparticles to improve drug permeation across cellular barriers and drug exposure to selective cell types. Frontiers in Pharmacology 2018, 9 .

022 Role of computer-aided drug design in modern drug discovery.  IF=2.49

4.C. Kim, J.Y. Axup, H. Yun, P.G. Schultz, J. Ma, J. Shen, P. Yang,“Targeting agent antibody conjugates and uses thereof” WO2014153164.

8:20

45.Kumar, V.; Choudhry, I.; Namdev, A.; Mishra, S.; Soni, S.; Hurkat, P.; Jain, A.; Jain, D., Oral insulin: Myth or reality. Current Diabetes Reviews 2018, 14 , 497 - 508.

Macalino, SJY, Gosu V, Hong S, and Cho S. (2015) Archives of Pharmacal Research 38(9), 1686-1701.

5.Y. Zhou, S. Lu, P. Yang, W. Wang, “Iridium catalyzed enantioselective hydrogenation of aromatic pyridines and pyrazines” CN1468852.

侯  波

46.Lamb, Y. N.; Syed, Y. Y., LY2963016 Insulin Glargine: A Review in Type 1 and 2 Diabetes. BioDrugs 2018, 32 , 91 - 98.

023 Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: in vitro, in vivo and in silico assessments. IF=3.975

B Hou

47.Li, C.; Huang, F.; Liu, Y.; Lv, J.; Wu, G.; Liu, Y.; Ma, R.; An, Y.; Shi, L., Nitrilotriacetic Acid-Functionalized Glucose-Responsive Complex Micelles for the Efficient Encapsulation and Self-Regulated Release of Insulin. Langmuir 2018, 34 , 12116-12125.

O’Shea JP, Faisal W, Ruane-O’Hora T, Devine, KJ, Kostewicz ES, O’Driscolla CM, and, Griffin BT (2015) European J Pharmaceutics and Biopharmaceutics, 96, 207-216.

M

48.Li, P.; Hao, J.; Li, H.; Guan, H.; Li, C., Development of an enteric nanoparticle of marine sulfated polysaccharide propylene glycol alginate sodium sulfate for oral administration: formulation design, pharmacokinetics and efficacy. Journal of Pharmacy and Pharmacology 2018, 70 , 740 - 748.

024 Development of a Physiologically Based Pharmacokinetic/Pharmacodynamic Model to Identify Mechanisms Contributing to Entacapone Low Bioavailability. IF=2.457

CHN

49.Lin, P.-Y.; Chiu, Y.-L.; Huang, J.-H.; Chuang, E.-Y.; Mi, F.-L.; Lin, K.-J.; Juang, J.-H.; Sung, H.-W.; Leong, K. W., Oral Nonviral Gene Delivery for Chronic Protein Replacement Therapy. Advanced Science 2018, 5 .

Alqahtani S and Kaddoumi A. (2015) Biopharmaceutics & Drug Disposition, accepted online.

10

50.Liu, L.; Zhang, Y.; Yu, S.; Yang, Z.; He, C.; Chen, X., Dual Stimuli-Responsive Nanoparticle-Incorporated Hydrogels as an Oral Insulin Carrier for Intestine-Targeted Delivery and Enhanced Paracellular Permeation. ACS Biomaterials Science and Engineering 2018, 4 , 2889 - 2902.

025 Homology Modeling, Molecular Dynamic Simulation and In Silico Screening of Activator for the Intensification of Human Sirtuin Type 1 (SIRT1) By Novel 1, 3, 4-Thiadiazole Derivatives-A Potential Antiaging Approach.  IF=2.457

张小军

51.Liu, L.; Zhang, Y.; Yu, S.; Zhang, Z.; He, C.; Chen, X., PH- and Amylase-Responsive Carboxymethyl Starch/Poly(2-isobutyl-acrylic acid) Hybrid Microgels as Effective Enteric Carriers for Oral Insulin Delivery. Biomacromolecules 2018, 19 , 2123 - 2136.

Saha S, Rai A, and Raj V. (2015) J Bioanal Biomed, Volume 7(4), 97-103.

X J Zzhang

52.Liu, M.; Wu, L.; Shan, W.; Cui, Y.; Huang, Y., Iron-mimic peptide converts transferrin from foe to friend for orally targeting insulin delivery. Journal of Materials Chemistry B 2018, 6 , 593 - 601.

026 Intestinal solubility and absorption of poorly water soluble compounds: predictions, challenges and solutions.  IF=4.87

M

53.Mahobia, S.; Bajpai, J.; Bajpai, Soya protein as possible potential nanocarriers for in-vitro oral delivery of insulin in simulated gastric fluids . International Journal of Polymeric Materials and Polymeric Biomaterials 2018, 67 , 340 - 350.

Fagerberg JH and Bergström CAS. (2015) Therapeutic Delivery online August.

CHN

54.Marya; Khan, H.; Nabavi, S. M.; Habtemariam, S., Anti-diabetic potential of peptides: Future prospects as therapeutic agents. Life Sciences 2018, 193, 153 - 158.

027 Using Cheminformatics in Drug Discovery. IF=3.872

4

55.McClements, D. J., Encapsulation, protection, and delivery of bioactive proteins and peptides using nanoparticle and microparticle systems: A review. Advances in Colloid and Interface Science 2018, 253, 1 - 22.

Lawless MS, Waldman M, Fraczkiewicz R, and Clark RD. (2015) Handbook of Experimental Pharmacology, Springer.

刘思言

56.Meneguin, A. i. B.; Beyssac, E.; Garrait, G.; Hsein, H.; Cury, B. S. F., Retrograded starch/pectin coated gellan gum-microparticles for oral administration of insulin: A technological platform for protection against enzymatic degradation and improvement of intestinal permeability. European Journal of Pharmaceutics and Biopharmaceutics 2018, 123, 84 - 94.

028 Identification of a major radiometabolite of [11C]PBB3. IF=2.529

S Y Liu

57.Moss, D. M.; Curley, P.; Kinvig, H.; Hoskins, C.; Owen, A., The biological challenges and pharmacological opportunities of orally administered nanomedicine delivery. Expert Review of Gastroenterology and Hepatology 2018, 12 , 223 - 236.

Hashimotoa H, Kawamuraa K, Takeia M, Igarashia N, Fujishiroa T, Shiomia S, Watanabea R, Mutoa M, Furutsukaa K, Itoa T, Yamasakia T, Yuia J, Nemotoa K, Kimuraa Y, Higuchia M, and Zhanga M-R. (2015) Nuclear Medicine and Biology, accepted online.

M

58.Nagy, C. r.; Einwallner, E., Study of in vivo glucose metabolism in high-fat diet-fed mice using oral glucose tolerance test and insulin tolerance test . Journal of Visualized Experiments 2018, 2018 .

029 Physical Stability of Drugs after Storage Above and Below the Glass Transition Temperature: Relationship to Glass-Forming Ability. IF=1.972

CHN

59.Nielsen, L. H.; Keller, S. S.; Boisen, A., Microfabricated devices for oral drug delivery. Lab on a Chip 2018, 18 , 2348 - 2358.

Alhalaweha A, Alzghoulb A, Mahlina D, and Bergström, CAS. (2015) International Journal of Pharmaceuticals, 405(1), 312-317.

3

60.Nishikawa, T.; Ono, K.; Hashimoto, S.; Kinoshita, H.; Watanabe, T.; Araki, H.; Otsu, K.; Sakamoto, W.; Harada, M.; Toyonaga, T.; Kawakami, S.; Fukuda, J.; Haga, Y.; Kukidome, D.; Takahashi, T.; Araki, E., One-hour oral glucose tolerance test plasma glucose at gestational diabetes diagnosis is a common predictor of the need for insulin therapy in pregnancy and postpartum impaired glucose tolerance. Journal of Diabetes Investigation 2018, 9 , 1370 - 1377.

030 Marine Drug Discovery Database (MDDD) – A Database of In silico Predicted Physico-Chemical, Drug Likeness and Toxicological Properties of Marine Compounds.  

4

61.Niu, Z.; Samaridou, E.; Jaumain, E.; Co?ne, J.; Ullio, G.; Shrestha, N.; Garcia, J.; Dur?n-Lobato, M.; Tovar, S.; Santander-Ortega, M. J.; Lozano, M. V.; Arroyo-Jimenez, M. M.; Ramos-Membrive, R. o.; Pe?uelas, I. n.; Mabondzo, A. s.; Pr?at, V. r.; Teixid, M.; Giralt, E.; Alonso, M. a. J., PEG-PGA enveloped octaarginine-peptide nanocomplexes: An oral peptide delivery strategy. Journal of Controlled Release 2018, 276, 125

Sripathy R, Vidya A, Balasubramanian V, Arokiaraj A, Ramchand CN, and Sundararaman M. (2015) Journal of Advanced Bioinformatics Applications and Research, 6(2), 33-44.

8:30

  • 139.

031-040

張修齊

62.Pandey, M.; Choudhury, H.; Yi, C. X.; Mun, C. W.; Phing, G. K.; Rou, G. X.; Singh, B. J. K. A. P. A. J.; Jhee, A. N. A.; Chin, L. K.; Kesharwani, P.; Gorain, B.; Hussain, Z., Recent updates on novel approaches in insulin drug delivery: A review of challenges and pharmaceutical implications. Current Drug Targets 2018, 19 , 1782 - 1800.

031 Discovery of novel S1P2 antagonists. Part 2: Improving the profile of a series of 1,3-bis(aryloxy)benzene derivatives. IF= 2.486

H C Chang

63.Pareek, M.; Bhatt, D. L.; Nielsen, M. L.; Jagannathan, R.; Eriksson, K.-F.; Nilsson, P. M.; Bergman, M.; Olsen, M. H., Enhanced predictive capability of a 1-hour oral glucose tolerance test: A prospective population-based cohort study. Diabetes Care 2018, 41 , 171 - 177.

Kusumia K, Shinozakib K, Yamauraa Y, Hashimotoa A, Kurataa H, Naganawaa A, Uedac H, Otsukia K, Matsushitaa T, Sekiguchia T, Kakuuchia A, and Sekoc T. (2015) Bioorg. Med. Chem. Letters online 8 Sept.

M

64.Qi, X.; Yuan, Y.; Zhang, J.; Bulte, J. W. M.; Dong, W., Oral Administration of Salecan-Based Hydrogels for Controlled Insulin Delivery. Journal of Agricultural and Food Chemistry 2018, 66 , 10479 - 10489.

032 1,4-Oxazine beta-secretase (BACE1) inhibitors: from hit generation to orally bioavailable brain penetrant leads. IF= 5.589

TPE

65.Rehmani, S.; Dixon, J. E., Oral delivery of anti-diabetes therapeutics using cell penetrating and transcytosing peptide strategies. Peptides 2018, 100, 24 - 35.

Rombouts FJR, Tresadern G, Delgado O, Lamenca CM, Van Gool M, García-Molina A, De Diego SAA, Oehlrich D, Prokopcova H, Alonso JM, Austin N, Borghys H, Van Brandt S, Surkyn M, De Cleyn M, Vos A, Alexander R, Macdonald GJ, Moechars D, Gijsen HJM, and Trabanco AA. (2015) J. Med. Chem. just accepted.

12

66.Rosales-Mendoza, S.; Nieto-G?mez, R., Green Therapeutic Biocapsules: Using Plant Cells to Orally Deliver Biopharmaceuticals. Trends in Biotechnology 2018, 36 , 1054 - 1067.

033 QSAR studies and design of new analogs of vitamin E with enhanced antiproliferative activity on MCF-7 breast cancer cells. IF=2.848

高景模

67.Schultz, W. M.; Varghese, T.; Heinl, R. E.; Dhindsa, D. S.; Mahlof, E. N.; Cai, H. C.; Southmayd, G.; Sandesara, P. B.; Eapen, D. J.; Sperling, L. S., Natural approaches in diabetes management: A review of diet, exercise, and natural products. Current Pharmaceutical Design 2018, 24 , 84 - 98.

Gagic Z, Nikolic K, Ivkovic B, Filipic S, and Agbaba, D. (2015) J Taiwan Inst Chem Eng August 20 online.

Go Kyeong Mo

68.Sgorla, D. b.; Lechanteur, A.; Almeida, A.; Sousa, F. v.; Melo, E.; Bunhak, l.; Mainardes, R.; Khalil, N.; Cavalcanti, O.; Sarmento, B., Development and characterization of lipid-polymeric nanoparticles for oral insulin delivery. Expert Opinion on Drug Delivery 2018, 15 , 213 - 222.

034 Effect of SI-591, a new class of cathepsin K inhibitor with peptidomimetic structure, on bone metabolism in vitro and in vivo.  IF=3.736

M

69.Shamsa, E. S.; Mahjub, R.; Mansoorpour, M.; Rafiee-Tehrani, M.; Dorkoosh, F. A., Nanoparticles prepared from N,N-Dimethyl-N-Octyl chitosan as the novel approach for oral delivery of insulin: Preparation, statistical optimization and in-vitro characterization. Iranian Journal of Pharmaceutical Research 2018, 17 , 442 - 459.

Fujii T, Ishikawa M, Kubo A, and Tanaka Y. (2015) Bone August 20 online.

KOR

70.Song, M.; Wang, H.; Chen, K.; Zhang, S.; Yu, L.; Elshazly, E. H.; Ke, L.; Gong, R., Oral insulin delivery by carboxymethyl-beta-cyclodextrin-grafted chitosan nanoparticles for improving diabetic treatment. Artificial Cells, Nanomedicine and Biotechnology 2018.

035 A Workflow to Investigate Exposure and Pharmacokinetic Influences on High-Throughput in Vitro Chemical Screening Based on Adverse Outcome Pathways. IF=8.443

7

71.Sun, Q.; Zhang, Z.; Zhang, R.; Gao, R.; McClements, D. J., Development of Functional or Medical Foods for Oral Administration of Insulin for Diabetes Treatment: Gastroprotective Edible Microgels. Journal of Agricultural and Food Chemistry 2018, 66 , 4820 - 4826.

Phillips MB, Leonard JA, Grulke CM, Chang DT, Edwards SW, Brooks R, Goldsmith MR, El-Masri H, Tan YM. (2015) Environ Health Perspect. May 15.

王宇聪

72.Tan, X.; Liu, X.; Zhang, Y.; Zhang, H.; Lin, X.; Pu, C.; Gou, J.; He, H.; Yin, T.; Zhang, Y.; Tang, X., Silica nanoparticles on the oral delivery of insulin. Expert Opinion on Drug Delivery 2018, 15 , 805 - 820.

036 An in silico expert system for the identification of eye irritants. IF=1.897

Y C Wang

73.Thwala, L. N.; Delgado, D. P.; Leone, K.; Marigo, I.; Benetti, F.; Chenlo, M.; Alvarez, C. V.; Tovar, S.; Dieguez, C.; Csaba, N. S.; Alonso, M. J., Protamine nanocapsules as carriers for oral peptide delivery. Journal of Controlled Release 2018, 291, 157 - 168.

Verma RP, Matthews EJ. (2015) SAR QSAR Environ Res. May;26(5):383-95.

M

74.Tian, H.; He, Z.; Sun, C.; Yang, C.; Zhao, P.; Liu, L.; Leong, K. W.; Mao, H.-Q.; Liu, Z.; Chen, Y., Uniform Core?Shell Nanoparticles with Thiolated Hyaluronic Acid Coating to Enhance Oral Delivery of Insulin. Advanced Healthcare Materials 2018, 7 .

037 In silico optimization of pharmacokinetic properties and receptor binding affinity simultaneously: a 'parallel progression approach to drug design' applied to ß-blockers.   IF=2.3

CHN

75.Tyagi, P.; Pechenov, S.; Anand, S., Oral peptide delivery: Translational challenges due to physiological effects. Journal of Controlled Release 2018, 287, 167 - 176.

Advani P, Joseph B, Ambre P, Pissurlenkar R, Khedkar V, Iyer K, Gabhe S, Iyer RP, Coutinho E. (2015) J Biomol Struct Dyn. May 20:1-15.

6

76.Villaverde Cendon, F.; Matos Jorge, R. M.; Weinschutz, R.; Mathias, A. L., Effect of matrix composition, sphere size and hormone concentration on diffusion coefficient of insulin for controlled gastrointestinal delivery for diabetes treatment. Journal of Microencapsulation 2018, 35 , 13 - 25.

038 Predicting the extent of metabolism using in vitro permeability rate measurements and in silico permeability rate predictions. IF=4.342

5

77.Wang, A.; Yang, T.; Fan, W.; Yang, Y.; Zhu, Q.; Guo, S.; Zhu, C.; Yuan, Y.; Zhang, T.; Gan, Y., Protein Corona Liposomes Achieve Efficient Oral Insulin Delivery by Overcoming Mucus and Epithelial Barriers. Advanced Healthcare Materials 2018.

Hosey CM, Benet LZ. (2015) Mol Pharm. May 4;12(5):1456-66.

8:40

78.Wang, X.; Cheng, D.; Liu, L.; Li, X., Development of poly(hydroxyethyl methacrylate) nanogel for effective oral insulin delivery. Pharmaceutical Development and Technology 2018, 23 , 351 - 357.

039 In silico prediction of hERG inhibition. IF=3.345

邢建福

79.Wong, C. Y.; Al-Salami, H.; Dass, C. R., Microparticles, microcapsules and microspheres: A review of recent developments and prospects for oral delivery of insulin. International Journal of Pharmaceutics 2018, 537 , 223 - 244.

Jing Y, Easter A, Peters D, Kim N, Enyedy IJ. (2015) Future Med Chem. Apr;7(5):571-86.

J F Xing

80.Wong, C. Y.; Al-Salami, H.; Dass, C. R., Recent advancements in oral administration of insulin-loaded liposomal drug delivery systems for diabetes mellitus. International Journal of Pharmaceutics 2018, 549 , 201 - 217.

040 Discovery of a Potent, Orally Available Dual CysLT1 and CysLT2 Antagonist with Dicarboxylic Acid.  IF=2.486

M

81.Wu, J.; Zheng, Y.; Liu, M.; Shan, W.; Zhang, Z.; Huang, Y., Biomimetic Viruslike and Charge Reversible Nanoparticles to Sequentially Overcome Mucus and Epithelial Barriers for Oral Insulin Delivery. ACS Applied Materials and Interfaces 2018, 10 , 9916 - 9928.

Itadani S, Takahashi S, Ima M, Sekiguchi T, Aratani Y, Egashira H, Matsumura N, Inoue A, Yonetomi Y, Fujita M, Nakayama Y, Takeuchi J. (2015) Bioorganic & Med. Chem. Mar 7

CHN

82.Xing, X.; Zhao, X.; Ding, J.; Liu, D.; Qi, G., Enteric-coated insulin microparticles delivered by lipopeptides of iturin and surfactin. Drug Delivery 2018, 25 , 23 - 34.

041-050

14

83.Xu, Y.; Zheng, Y.; Wu, L.; Zhu, X.; Zhang, Z.; Huang, Y., Novel Solid Lipid Nanoparticle with Endosomal Escape Function for Oral Delivery of Insulin. ACS Applied Materials and Interfaces 2018, 10 , 9315 - 9324.

041 The importance of critical micellar concentration for the prediction of solubility enhancement in biorelevant media.   IF=4.342

孔凡秋

84.Yu, J.; Zhang, Y.; Wang, J.; Wen, D.; Kahkoska, A. R.; Buse, J. B.; Gu, Z., Glucose-responsive oral insulin delivery for postprandial glycemic regulation. Nano Research 2018.

Ottaviani G, Wendelspiess S, Alvarez-Sanchez R. (2015) Mol Pharm. Feb 9.

F Q Kong

85.Zhang, H.; Wang, W.; Li, H.; Peng, Y.; Zhang, Z., Microspheres for the oral delivery of insulin: preparation, evaluation and hypoglycaemic effect in streptozotocin-induced diabetic rats. Drug Development and Industrial Pharmacy 2018, 44 , 109 - 115.

042 The influence of salt chaotropicity, column hydrophobicity and analytes’ molecular properties on the retention of pramipexole and its impurities.  IF=3.926

M

86.Zhang, L.; Qin, H.; Li, J.; Qiu, J.-N.; Huang, J.-M.; Li, M.-C.; Guan, Y.-Q., Preparation and characterization of layer-by-layer hypoglycemic nanoparticles with pH-sensitivity for oral insulin delivery. Journal of Materials Chemistry B 2018, 6 , 7451 - 7461.

Vemic A, Kalinic M, Eric S, Malenovica A, Medenicac M. (2015) J. of Chromatography Feb. 1

CHN

87.Zhang, Y.; Zhang, L.; Ban, Q.; Li, J.; Li, C.-H.; Guan, Y.-Q., Preparation and characterization of hydroxyapatite nanoparticles carrying insulin and gallic acid for insulin oral delivery. Nanomedicine: Nanotechnology, Biology, and Medicine 2018, 14 , 353 - 364.

043 Evaluation and comparison of benchmark QSAR models to predict a relevant REACH endpoint: The bioconcentration factor (BCF). IF=2.76

5

88.Zheng, Y.; Wu, J.; Shan, W.; Wu, L.; Zhou, R.; Liu, M.; Cui, Y.; Zhou, M.; Zhang, Z.; Huang, Y., Multifunctional Nanoparticles Enable Efficient Oral Delivery of Biomacromolecules via Improving Payload Stability and Regulating the Transcytosis Pathway. ACS Applied Materials and Interfaces 2018.

Gissi A, Lombardo A, Roncaglioni A, Gadaleta D, Mangiatordi GF, Nicolotti O, Benfenati E. (2015) Environ Res. Jan 20;137C:398-409

孙晓伟

89.Zhuravlyeva, N. N.; Krasnoshtanova, A. A. b., Development of the chitosan-alginate microparticle based system for the delivery of insulin. Russian Journal of Biopharmaceuticals 2018, 10 , 15 - 20.

044 Prediction of blood-brain barrier permeation of a-adrenergic and imidazoline receptor ligands using PAMPA technique and quantitative-structure permeability relationship analysis. IF=3.773

X W Sun

90.Ziegler; Ohli; Hoefs; Aydin; Falk; Gross, Early detection and primary prevention of type?1 diabetes: Global Platform for the Prevention of Autoimmune Diabetes . Diabetologe 2018, 14 , 240 - 244.

Vucicevic J, Nikolic K, Dobricic V, Agbaba D. (2015) Eur J Pharm Sci. 68C:94-105

M

91.CROSS-LINKED MALTODEXTRINS FOR THE ORAL DELIVERY OF BIOLOGICAL ACTIVES. EP3427725, 2019.

045 Comparison of in silico tools for evaluating rat oral acute toxicity.  IF=1.897

CHN

92.Abramson, A.; Caffarel-Salvador, E.; Khang, M.; Dellal, D.; Silverstein, D.; Gao, Y.; Frederiksen, M. R.; Vegge, A.; Hubálek, F.; Water, J. J.; Friderichsen, A. V.; Fels, J.; Kirk, R. K.; Cleveland, C.; Collins, J.; Tamang, S.; Hayward, A.; Landh, T.; Buckley, S. T.; Roxhed, N.; Rahbek, U.; Langer, R.; Traverso, G., An ingestible self-orienting system for oral delivery of macromolecules. Science Translational Medicine 2019, 363 , 611-615.

Diaza RG, Manganelli S, Esposito A, Roncaglioni A, Manganaro A, Benfenati E. (2015) SAR QSAR Environ Res. Jan 8:1-27

13

93.Boushra, M.; Tous, S.; Fetih, G.; Xue, H.-Y.; Wong, H.-L., Development of bi-polymer lipid hybrid nanocarrier to improve the entrapment and stability of insulin for efficient oral delivery. Journal of Drug Delivery Science and Technology 2019, 49, 632 - 641.

046 Design,Synthesis and Pharmacological evaluation of N-[4-(4-(alkyl/aryl/heteroaryl/)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents.  IF=2.486

6

94.Kuipers, A.; Moll, G. N.; Wagner, E.; Franklin, R., Efficacy of lanthionine-stabilized angiotensin- in type I and type II diabetes mouse models. Peptides 2019, 112, 78 - 84.

Kumari S, Mishra CB, Tiwari M. (2015) Bioorganic & Medicinal Chemistry Letters Jan. 9

8:50

95.Liu, C.; Kou, Y.; Zhang, X.; Dong, W.; Cheng, H.; Mao, S., Enhanced oral insulin delivery via surface hydrophilic modification of chitosan copolymer based self-assembly polyelectrolyte nanocomplex. International Journal of Pharmaceutics 2019, 554, 36 - 47.

047 Computational classification models for predicting the interaction of drugs with P-glycoprotein and breast cancer resistance protein. IF=1.897

王一辰

96.Mart?nez, L. p.; Carvajal, M.; Sotelo, C.; Micard; Rasc?n, C.; Franco, L. p.; Lizardi, M.; Canett, R., Enzymatically cross-linked arabinoxylan microspheres as oral insulin delivery system. International Journal of Biological Macromolecules 2019, 126, 952 - 959.

Eric S, Kalinic M, Ilic K, Zloh M. (2014) SAR QSAR Environ Res. 25(12):955-82

Y C Wang

97.Sun, L.; Liu, Z.; Tian, H.; Le, Z.; Liu, L.; Leong, K. W.; Mao, H.-Q.; Chen, Y., Scalable Manufacturing of Enteric Encapsulation Systems for Site-Specific Oral Insulin Delivery. Biomacromolecules 2019, 20 , 528 - 538.

048 Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug.IF=10.103

M

98.Tan, S. Y.; Mei Wong, J. L.; Sim, Y. J.; Wong, S. S.; Mohamed Elhassan, S. A.; Tan, S. H.; Ling Lim, G. P.; Rong Tay, N. W.; Annan, N. C.; Bhattamisra, S. K.; Candasamy, M., Type 1 and 2 diabetes mellitus: A review on current treatment approach and gene therapy as potential intervention. Diabetes and Metabolic Syndrome: Clinical Research and Reviews 2019, 13 , 364 - 372.

Doeser A, Dickhof G, Reitze M, Uebachs M, Schaub C, Pires NM, Bonifácio MJ, Soares-da-Silva P, Beck H. (2014) Brain. Dec 2.

CHN

99.Tsai, L.-C.; Chen, C.-H.; Lin, C.-W.; Ho, Y.-C.; Mi, F.-L., Development of mutlifunctional nanoparticles self-assembled from trimethyl chitosan and fucoidan for enhanced oral delivery of insulin. International Journal of Biological Macromolecules 2019, 126, 141 - 150.

049 Estimation of the chemical-induced eye injury using a weight-of-evidence (WoE) battery of 21 artificial neural network (ANN) c-QSAR models (QSAR-21): Part I: Irritation potential.  IF=2.227

3

100.Vasconcelos Silva, E. d. L.; Oliveira, A. n. C. d. J.; Patriota, Y. B. l. G.; Ribeiro, A. n. J.; Veiga, F.; Hallwass, F.; Silva-Filho, E. C.; da Silva, D. A.; Soares, M. F. d. L. R.; Wanderley, A. G. a.; Soares-Sobrinho, J. L., Solvent-free synthesis of acetylated cashew gum for oral delivery system of insulin. Carbohydrate Polymers 2019, 207, 601 - 608.

Verma RP, Matthews EJ. (2014) Regul Toxicol Pharmacol. pii: S0273-2300(14)00286-4

邹林云

050 Estimation of the chemical-induced eye injury using a Weight-of-Evidence (WoE) battery of 21 artificial neural network (ANN) c-QSAR models (QSAR-21): Part II: Corrosion potential.   IF=2.227

L Y Zou

Verma RP, Matthews EJ. (2014) Regul Toxicol Pharmacol. pii: S0273-2300(14)00297-9 

M

051-060

CHN

051 Isoxazolotacrines as non-toxic and selective butyrylcholinesterase inhibitors for Alzheimer's disease. IF=3.345

4

Cherif O, Allouche F, Chabchoub F, Chioua M, Soriano E, Yañez M, Cacabelos R, Romero A, López MG, Marco-Contelles J. (2014) Future Med Chem. 6(17):1883-91.

方巴斯腾

052  Best of Both Worlds: Combining Pharma Data and State of the Art Modeling Technology to Improve in silico pKa Prediction. IF=3.657

B S T Fang

Fraczkiewicz R, Lobell M, Göller AH, Krenz U, Schoenneis R, Clark RD, Hillisch A. (2014) J. Chem. Inf. Model. (Just Accepted Manuscript)

M

053 Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis.  IF=3.057

CHN

Pedersen C, Slepenkin A, Andersson SB, Fagerberg JH, Bergström CA, Peterson EM. (2014) PLoS One. Oct 30;9(10)

8

054 Relationships between the antidotal efficacy and structure, PK/PD parameters and bio-relevant molecular descriptors of AChE reactivating oximes: inclusion and integration to biopharmaceutical classification systems. IF=2.598

7

Voicu V, Radulescu FS, Medvedovici A. (2014) Expert Opin Drug Metab Toxicol. Nov 6:1-15

9:00

055 Three-Dimensional Quantitative Structure-Activity Relationship Analysis for Human Pregnane X Receptor for the Prediction of CYP3A4 Induction in Human Hepatocytes: Structure-Based Comparative Molecular Field Analysis.  IF=2.641

辜柏雲

Handa K, Nakagome I, Yamaotsu N, Gouda H, Hirono S. (2014) J Pharm Sci. Nov 7

P Y Ku

056 A combination of pharmacophore modeling, molecular docking, and virtual screening for P2Y12 receptor antagonists from Chinese herbs. IF=1.066

M

He Y, Jiang L, Yang Z, Qiao Y, Zhang YL. (2014) Canadian J. Chem. Nov 18

TPE

057 Ranking the binding energies of p53 mutant activators and their ADMET properties. IF=2.802

8

Omar SI, Tuszynski J. (2014) Chem Biol Drug Des. Nov 19.

吴天一

058 Concomitant intake of alcohol may increase the absorption of poorly soluble drugs.  IF=2.73

T Y Wu

Fagerberg JH, Sjögren E, Bergström CAS. (2014) Eur. J. Pharm. Sci. 67:12-20

M

059 Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification. IF=5.589

CHN

Sit RK, Fokin VV, Amitai G, Sharpless KB, Taylor P, Radic Z. (2014) J Med Chem. Feb 27;57(4):1378-89.

5

060 Improving genetic programming for the prediction of pharmacokinetic parameters. IF=2.209

沈楠楠

Vanneschi L. (2014) Memetic Computing Oct 26

N N Shen

061-070

M

061 Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: A comparison with carbamazepine, oxcarbazepine and lacosamide.  IF=4.936

CHN

Hebeisen S, Pires N, Loureiro AI, Bonifácio MJ, Palma N, Whyment A, Spanswick D, Soares-da-Silva P. (2014) Neuropharmacology. Sep 19;89C:122-135

13

062 The Poorly Membrane Permeable Antipsychotic Drugs Amisulpride and Sulpiride Are Substrates of the Organic Cation Transporters from the SLC22 Family.  IF= 3.819

8

Dos Santos Pereira JN, Tadjerpisheh S, Abed MA, Saadatmand AR, Weksler B, Romero IA, Couraud PO, Brockmöller J, Tzvetkov MV. (2014) AAPS J. Aug 26.

9:10

063 In Silico Prediction of Major Drug Clearance Pathways by Support Vector Machines with Feature-Selected Descriptors.  IF= 3.21

于超宇

Toshimoto K, Wakayama N, Kusama M, Maeda K, Sugiyama Y, Akiyama Y. (2014) Drug Metab Dispos. Aug 14

C Y Yu 

064 Synthesis and Antioxidant Activity Evaluation of New Compounds from Hydrazinecarbothioamide and 1,2,4-Triazole Class Containing Diarylsulfone and 2,4-Difluorophenyl Moieties.  IF= 3.257

M

Barbuceanu SF, Ilies DC, Saramet G, Uivarosi V, Draghici C, Radulescu V. (2014) Int. J. Mol. Sciences 15:10908-10925

CHN

065 Comparison of in silico models for prediction of Daphnia magna acute toxicity. IF= 1.897

5

Golbamaki A, Cassano A, Lombardo A, Moggio Y, Colafranceschi M, Benfenati E. (2014) SAR QSAR Environ Res. Jun 9:1-22.

刘  强

066 Non-linear assessment of anticancer activity of 17-picolyl and 17-picolinylidene androstane derivatives – Chemometric guidelines for further syntheses.  IF= 3.773

Q Liu

Kovacevic SZ, Podunavac-Kuzmanovic SO, Jevric LR, Djurendic EA, Ajdukovic JJ. (2014) Eur J Pharm Sci. Jun 11.

M

067 A tutorial for analysing the cost-effectiveness of alternative methods for assessing chemical toxicity: the case of acute oral toxicity prediction. IF=1.021

CHN

Norlen H, Worth AP, Gabbert S. (2014) Altern Lab Anim. May;42(2):115-27.

5

068 Using beta binomials to estimate classification uncertainty for ensemble models.  IF= 3.949

林鼎勝

Clark RD, Liang W, Lee AC, Lawless MS, Fraczkiewicz R, Waldman M. (2014) J. of Cheminfo. 6:34

D S Lin 

069 BU08073 a Buprenorphine Analog with Partial Agonist Activity at mu Receptors in vitro but Long-Lasting Opioid Antagonist Activity in vivo in Mice.   IF= 5.259

M

Khroyan TV, Wu J, Polgar WE, Cami-Kobeci G, Fotaki N, Husbands SM, Toll L. (2014) Br J Pharmacol. Jun 5

TPE

070 N-(furan-2-ylmethyl)-N-methylprop-2-yn-1-amine (F2MPA): A Potential Cognitive Enhancer with MAO Inhibitor Properties.   IF= 4.019

5

Di Giovanni G, García I, Colangeli R, Pierucci M, Rivadulla ML, Soriano E, Chioua M, Della Corte L, Yáñez M, De Deurwaerdère P, Fall Y, Marco-Contelles J. (2014) CNS Neurosci Ther. May 21

9

9:20

陈子涵

T H Chen

F

TPE

2

青野纱也

Aono Saya

F

JPN

4

肖佳艺

J Y Xiao

F

CHN

5

10

9:30

殷子珺

Z J Yin

F

CHN

6

王馨迎

X Y Wang

F

CHN

8

 

 

 

 

 

11

9:40

吉  融

R Ji

F

CHN

1

张维维

W W Zhang

F

CHN

3

孟  霖

L Meng

F

CHN

13

12

9:50

蔡丹婷

D T Cai

F

CHN

8

吴  莎

S Wu

F

CHN

3

高天祺

T Q Gao

F

CHN

10

13

10:00

吕  政

 Z Lv

F

CHN

10

高美祺

M Q Gao

F

CHN

5

肖琪锋

Q F Xiao

F

CHN

12

14

10:10

林冶舟

Y Z Lin

F

CHN

9

朱晓宇

X Y Zhu

F

CHN

4

 

 

 

 

 

Round 2 (October 15, 2011)   DRAW —— Tee 10

FLIGHT

 TIME

 PLAYER

GENDER

FROM

TO PAR

15

8:00

周  天

T Zhou  

M

CHN

1

黄文程

W C Huang

M

CHN

10

 

 

 

 

 

16

8:10

金  城

C Jin 

M

CHN

6

徐清权

Q Q Xu

M

CHN

9

韩  良

L Han

M

CHN

8

17

8:20

Abdul拉

Sultan Abdulla

M

BHR

12

羅騏豪

C H Lo

M

TPE

7

徐国振

G Z Xu

M

CHN

3

18

8:30

李  源

Y Li

M

CHN

2

佘梓瀚

Z H She

M

CHN

12

赵梓潼

Z T Zhao

M

CHN

4

19

8:40

窦泽成

Z C Dou

M

CHN

2

张蕙麟

H L Zhang

M

CHN

5

 

 

 

 

 

20

8:50

郑在亨

Jeong Jay Hyeong

M

KOR

10

陈泽山川

Z S C Chen      

M

CHN

11

刘宇翔

Y X Liu

M

CHN

4

21

9:00

关天朗

T L Guan

M

CHN

2

尾崎秀平

Ozaki Shuhei

M

JPN

3

Mohammed

Mohamed Alnoaimi  

M

BHR

11

22

9:10

曹  一

Y Cao

M

CHN

E

王曦晨

X C Wang 

M

CHN

5

吴豪川

H C Wu

M

CHN

4

23

9:20

陈利庆

L Q Chen

F

CHN

8

刘娟娟

J J Liu

F

CHN

7

王紫依(A)

Z Y Wang(A)

F

CHN

6

24

9:30

冈村优

Yu Okamura

F

JPN

E

王梓漪(B) 

Z Y  Wang(B)

F

CHN

-1

馬家嵋

C M MA 

F

TPE

11

25

9:40

维多帕罗奥图

Ma. Andrea Victoria Unson

F

PHI

-1

杨嘉欣

J X Yang

F

CHN

E

 

 

 

 

 

26

9:50

李惠晶

Lee Hye Jung

F

KOR

6

张婕娜琳

J N L Zhang

F

CHN

7

黄以柔

Y R Huang

F

TPE

6

27

10:00

周佳怡

J Y Zhou

F

CHN

2

王梅杏

M X Wang

F

CHN

3

张芸杰

Y J Zhang

F

CHN

10

编辑:科学研究 本文来源:小分子再生医学药物的发现到多肽,业余高尔夫

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